Willow bark-derived material with antimicrobial and antibiofilm properties for potential wound dressing applications (2023)

Dou , J. , Ilina , P. , Cruz , C. D. , Nurmi , D. , Vidarte , P. Z. , Rissanen , M. , Tammela , P. ,.(2023).Willow bark-derived material with antimicrobial and antibiofilm properties for potential wound dressing applications.Journal of Agricultural and Food Chemistry.https://doi.org/10.1021/acs.jafc.3c00849

Dou, Kinze; Irina, Polina; Cruz, Christina, D. et al. /Willow bark-derived material with antimicrobial and antibiofilm properties for potential wound dressing applications.In publications:Journal of Agricultural and Food Chemistry. 2023.

@Artikel {cd1fe9634c0247569ed2cd08282113a7,

title = "Pilge bark-derived material with antimicrobial and antibiofilm properties for potential wound dressing applications",

summary = "The stem contains wood in addition to 10-20% of the bark, which remains one of the largest underutilized sources of biomass on Earth. The unique macromolecules (eg, lignin, suberin, pectin, and tannins) , extracts and scleral fibers constitute Here we present to study in detail the antimicrobial and antibiofilm properties of bark-derived fiber bundles and discuss their use as dressings for the treatment of infections Possible application in chronic wounds isolated strains of Staphylococcus aureus significant. We then correlated the antimicrobial activity of the material with its chemical composition. Lignin plays an important role in the antimicrobial activity against planktonic bacteria [i.e., minimum inhibitory concentration (MIC) 1.25 mg/mL] Acetone extract (rich in unsaturated fatty acids) and tannins (rich in dicarboxylic acids) Substances inhibited bacterial plankton growth [MIC of 1 and 3 mg/mL, respectively] and biofilm formation According to X-ray photoelectron spectroscopy, the yarn lost its antimicrobial activity when the surface lignin reached 20.1%. The fiber bundles in the yarn ratio were positively correlated with their surface lignin. Overall, this study paves the way for the use of bark-derived fiber bundles as natural materials for active (antibacterial and antibiofilm) wound dressings, bringing this undervalued recycling of bark waste from energy to high-value medical applications. ".

Keywords = "bark biorefining, chemical structure-property relationships, lignin, natural functions, unsaturated fatty acids, willow bark fiber bundles, wound dressing",

author = "Jinze Dou and Polina Ilina and Cruz, {Cristina D.} and Denise Nurmi and Vidarte, {Paula Zegarra} and Marja Rissanen and P{\"a}ivi Tammela and Tapani Vuorinen",

note = "Funding information: This work used the Aalto University Bioeconomy Fund. We are grateful to the University of Helsinki (HiLIFE) and the DDCB Central Fund for the support of the Finnish biocentre. This work is part of the {\ textquoteright} of the flagship project of the Academy of Finland with numbers 318890 and 318891 (Competence Center for Materials Bioeconomy, FinnCERES) and the BioColour project, supported by the Strategic Research Council of the Academy of Finland (funding numbers 327178, 327213 and 327195) .Publisher's Copyright: { \textcopyright} 2023 The Authors .Published by the American Chemical Society.",

Year = "2023",

month = April,

day = "27",

doi = "10.1021/acs.jafc.3c00849",

Language = "English",

tidsskrift = "Journal of Agricultural and Food Chemistry",

issn = "0021-8561",

udgiver = "American Chemical Society",

}

Dou, J, Ilina, P, Cruz, CD, Nurmi, D, Vidarte, PZ, Rissanen, M, Tammela, P2023, 'Willow bark-derived material with antimicrobial and antibiofilm properties for potential wound dressing applications',Journal of Agricultural and Food Chemistry.https://doi.org/10.1021/acs.jafc.3c00849

Willow bark-derived material with antimicrobial and antibiofilm properties for potential wound dressing applications./ Dou, Kanazawa; Irina, Polina; Cruz, Christina, D. et al.

In publications:Journal of Agricultural and Food Chemistry, 27.04.2023.

Results of the investigation:Magazine article›article›scientific›Peer Review

TY - 日

T1 – Willow bark-derived material with antimicrobial and antibiofilm properties for potential wound dressing applications

AU - Dou, Jinze

AU - Ilina, Poland

AU-Cruz, Cristina D.

ES - Nurmi, Denise

AU - Vidarte, Paula Zegara

ES - Rissanen, Marja

ES - Tammela, Päivi

EN - Vorinen, Tappany

N1 - Funding information: This work used the Aalto University Bioeconomy Fund. We are very grateful to the DDCB central facility supported by the University of Helsinki (HiLIFE) and the Finnish biocentre. This work is part of the flagship program of the Academy of Finland under project numbers 318890 and 318891 (Competence Center for the Bioeconomy of Materials, FinnCERES) and the BioColour project supported by the Strategic Research Council of the Academy of Finland (numbers of financing 327178, 327213 and 327195). Editorial Copyright: © 2023 Author. Published by the American Chemical Society.

Year - 4/27/2023

Year 1 - 2023/4/27

N2: The trunk contains wood beyond 10-20% of the bark, which remains one of the largest underutilized sources of biomass on the planet. Unique macromolecules (such as lignin, suberin, pectin, and tannin), extractives, and scleral fibers make up the main part of the bark. Here, we perform a detailed investigation of the antibacterial and antibiofilm properties of bark-derived fiber bundles and discuss their potential use as dressings for the treatment of chronically infected wounds. We show that yarn containing at least 50% willow bark fiber bundles significantly inhibits biofilm formation by S. aureus strains isolated from wounds. We then correlated the antimicrobial effect of the material with its chemical composition. Lignin plays an important role in antimicrobial activity against planktonic bacteria [ie, minimum inhibitory concentration (MIC) 1.25 mg/ml]. Acetone extract (rich in unsaturated fatty acids) and tannin-like substances (rich in dicarboxylic acids) inhibited bacterial plankton growth [MIC 1 and 3 mg/ml, respectively] and biofilm formation. According to X-ray photoelectron spectroscopy, the yarn lost its antimicrobial activity when the surface lignin reached 20.1%. The proportion of fiber bundles in the yarn was positively correlated with its surface lignin. Overall, this study paves the way for the use of bark-derived fiber bundles as natural materials for active (antibacterial and anti-biofilm) wound dressings, upgrading this energy-undervalued bark residue to high-value pharmaceutical applications.

AB - The trunk contains wood in addition to 10-20% of the bark, which is still one of the largest underused biomass on the planet. Unique macromolecules (such as lignin, suberin, pectin, and tannin), extractives, and scleral fibers make up the main part of the bark. Here, we perform a detailed study of the antibacterial and antibiofilm properties of bark-derived fiber bundles and discuss their potential use as dressings for the treatment of chronically infected wounds. We show that yarn containing at least 50% willow bark fiber bundles significantly inhibits biofilm formation by S. aureus strains isolated from wounds. We then correlated the antimicrobial effect of the material with its chemical composition. Lignin plays an important role in antimicrobial activity against planktonic bacteria [ie, minimum inhibitory concentration (MIC) 1.25 mg/ml]. Acetone extract (rich in unsaturated fatty acids) and tannin-like substances (rich in dicarboxylic acids) inhibited bacterial plankton growth [MIC 1 and 3 mg/ml, respectively] and biofilm formation. According to X-ray photoelectron spectroscopy, the yarn lost its antimicrobial activity when the surface lignin reached 20.1%. The proportion of fiber bundles in the yarn was positively correlated with its surface lignin. Overall, this study paves the way for the use of bark-derived fiber bundles as natural materials for active (antibacterial and anti-biofilm) wound dressings, upgrading this energy-undervalued bark residue to high-value pharmaceutical applications.

KW - Corteza Bioraffinade

KW - Chemical structure-property relationships

KW-lignin

KW - natural function

KW - unsaturated fatty acids

KW——bark fiber bundle

KW - wound dressing

Dig: http://www.scopus.com/inward/record.url?scp=85156272737&partnerID=8YFLogxK

U2 - 10.1021/acs.jafc.3c00849

hacer - 10.1021/acs.jafc.3c00849

M3 - Artillery

AN-SCOPUS:85156272737

JO - Journal of Agricultural and Food Chemistry

JF - Journal of Agricultural and Food Chemistry

Serial number - 0021-8561

Y -

Dou J, Ilina P, Cruz CD, Nurmi D, Vidarte PZ, Rissanen M.Willow bark-derived material with antimicrobial and antibiofilm properties for potential wound dressing applications.Journal of Agricultural and Food ChemistryApril 27, 2023. Available electronically April 27, 2023. doi: 10.1021/acs.jafc.3c00849